Pharmaceuticals

Microscopy is a key component in the research, formulation and manufacturing stages of pharmaceutical product development. Understanding and optimizing particle size, morphology and roughness of pharmaceutical materials is extremely important when developing a new drug compound and its delivery vehicle. Scanning electron microscopy (SEM) and optical microscopy are commonly used to assist in the optimization of these properties.

Image strip for Pharmaceutical Applications

Understanding the size distribution and morphology of pharmaceutical particles containing either active pharmaceutical ingredients (API) or excipients is critical when optimizing dissolution rates of materials and compounding processes. Coupled with automated data acquisition and particle analysis software, SEM is ideal for determining the size and morphology of particles. Further, the chemical composition of particles in any given batch needs to be characterized when analyzing the efficacy of mixing or when checking for foreign particulate matter. SEM can also be paired with energy-dispersive X-ray spectroscopy (EDS) to analyze the chemical composition of individual particles with the Phenom ProX SEM.

Polarized light and interference contrast microscopies are used to investigate the crystal structure of components or elucidate solid or semi-solid particles suspended in a medium of similar contrast like a polymer or liquid. The Zeta-20 3D optical profiler is an extendable metrology platform that provides complete several different optical analyses including enhanced differential interference contrast (ZIC) in addition to the standard 3D profilometry. 


Particles

Particles

Particle distribution, morphology and chemical composition

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Quality Assurance

Quality Assurance

SEM imaging and EDS analysis applied to pharmaceutical QA/QC

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Deformulation

Deformulation

Deformulation, also referred to as reverse engineering, for the pharmaceutical industry

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Surfaces and Coatings

Surfaces and Coatings

Characterize pharmaceutical surfaces and coatings with 3D profilometry, AFM, SEM and elemental analysis

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Products for Pharmaceutical Materials Characterization

Products for Pharmaceutical Materials Characterization

Microscopy products to characterize pharmaceutical excipients, API, tablets, and coatings

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Pharmaceuticals Testimonials

Pharmaceuticals Testimonials

Case studies using the Phenom SEM for pharmaceutical and medical research

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