Automated Particle Analysis for Pharmaceutical Applications

Particle morphology and distribution are important parameters for pharmaceutical applications. Multiple samples can be imaged in batch and automatically be analyzed, reducing operator bias.

Scanning electron microscopy (SEM) coupled with batch generation and automated particle analysis software is ideal for characterizing particle size and morphology. Using particle analysis ParticleMetric software for the Phenom SEM, false color is used to indicate individual particles while the software compiles statistics for the sample.

Pharmaceutical powder ParticleMetricPharmaceutical powder particles selected for analysis with ParticleMetric software for the Phenom SEM

Several parameters for particle morphology can be measured with the ParticleMetric software, including:

  • Diameter
  • Circularity
  • Aspect ratio
  • Major axis
  • Minor axis
  • Circumference

Circularity example using ParticleMetric software

Example of Circularity analysis with ParticleMetric for the Phenom SEM